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Meta-Analysis
. 2012 Nov 28:12:328.
doi: 10.1186/1471-2334-12-328.

Association between tumor necrosis factor alpha-238G/a polymorphism and tuberculosis susceptibility: a meta-analysis study

Zhijiao Zhang  1 , Hang Zhu, Xudi Pu, Siying Meng, Fan Zhang, Lei Xun, Qin Liu, Yang Wang
Affiliations
Meta-Analysis

Association between tumor necrosis factor alpha-238G/a polymorphism and tuberculosis susceptibility: a meta-analysis study

Zhijiao Zhang et al. BMC Infect Dis. .

Abstract

Background: Tumor necrosis factor alpha (TNF-α) plays a key role in the containment of tuberculosis. The relationship between the TNF -238G/A polymorphism and tuberculosis susceptibility remains inconclusive. A comprehensive meta-analysis was made to provide a more precise estimate of the relationship between them.

Methods: Multiple search strategies were used. A fixed effect model was takentook to estimate pooled OR with 95% confidence interval (CI) for the association between the TNF -238G/A polymorphism and tuberculosis susceptibility. The Chi-squared-based Q-test and I-squaredI2 statistic were calculated to examine heterogeneity. Begg's funnel plot and Egger's test were used to assess publication bias.

Results: 9 case-control studies were included in this meta-analysis. No significant heterogeneity was demonstrated, and no obvious publication bias was detected among the included studies. The meta-analysis indicated that there was no significant association between the TNF -238G/A polymorphism and tuberculosis susceptibility (GA+AA versus GG model: OR=1.005, 95% CI: 0.765-1.319; A versus G model: OR=1.000, 95% CI: 0.769-1.300). In the subgroup analyses by ethnicity, types of TB and human immunodeficiency virus (HIV) status, no significant association were identified.

Conclusions: The meta-analysis involving 2723 subjects did not detect any association between the TNF -238G/A polymorphism and tuberculosis susceptibility.

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Figures

Figure 1
Figure 1
Flow diagram of selection process.
Figure 2
Figure 2
Forest plots of associations between TNF-238 SNP and TB susceptibility in GA+AA vs GG model.
Figure 3
Figure 3
Forest plots of associations between TNF-238 SNP and TB susceptibility in A vs G model.
Figure 4
Figure 4
Begg’s funnel plot for publication bias in GA+AA vs AA genotype model.
Figure 5
Figure 5
Begg’s funnel plot for publication bias in A vs G genotype model.
See this image and copyright information in PMC

References

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