Recent approaches for C-C bond formation via direct dehydrative coupling strategies

Abstract

In recent years, reaction of inexpensive and abundantly available alcohols (C-OH) with unactivated nucleophilic coupling partners (C-H), leading to the construction of the C-C bond, has emerged as one of the vital strategies since it is an atom-economical and environmentally benign approach with water as the by-product. Various transition metal-catalyzed or metal-free approaches for the direct dehydrative coupling employing the C-OH bond (including in situ activation) have recently been devised. This review article aims to highlight advances in such waste-free C-C bond forming dehydrative strategies.