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. 2013 Feb 1;9(2):260-2.
doi: 10.4161/auto.22783. Epub 2012 Nov 28.

Hypoxia, MTOR and autophagy: converging on senescence or quiescence

Mikhail V Blagosklonny  1
Affiliations

Hypoxia, MTOR and autophagy: converging on senescence or quiescence

Mikhail V Blagosklonny. Autophagy. .

Abstract

Although hypoxia can cause cell cycle arrest, it may simultaneously suppress a conversion from this arrest to senescence. Furthermore, hypoxia can suppress senescence caused by diverse stimuli, maintaining reversible quiescence instead. Hypoxia activates autophagy and inhibits MTOR, thus also activating autophagy. What is the relationship between autophagy and cellular senescence? Also, can inhibition of MTOR and stimulation of autophagy explain the gerosuppressive effects of hypoxia?

Keywords: aging; autophagy; oxygen; rapamycin; senescence.

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Figure 1. The relationship between hypoxia, MTOR, growth, senescence and autophagy. Arrows, stimulation; brakes, inhibition. Green lines, positive effect on cellular mass/size growth; red lines, negative effects. GF, growth factors.
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Comment on

  • Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV. Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A. 2012;109:13314–8. doi: 10.1073/pnas.1205690109.

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