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. 2013 May;9(5):940-3.
doi: 10.1039/c2mb25388g.

Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein

Toshio Maki  1 , Akie Kawamura, Nobuo Kato, Junko Ohkanda
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Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein

Toshio Maki et al. Mol Biosyst. 2013 May.

Abstract

The template effect of 14-3-3 protein on the chemical ligation of fusicoccin derivatives containing an epoxide group and the pentapeptide QSYDC was investigated. HPLC analysis of the epoxide-opening reaction demonstrated that 14-3-3ζ protein improves the yield of the conjugate product compared to the protein-free control.

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