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. 2013 Mar;60(3):508-11.
doi: 10.1002/pbc.24402. Epub 2012 Nov 28.

Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database

Marko Kavcic  1 , Brian T Fisher, Kari Torp, Yimei Li, Yuan-Shung Huang, Alix E Seif, Marijana Vujkovic, Richard Aplenc
Affiliations

Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database

Marko Kavcic et al. Pediatr Blood Cancer. 2013 Mar.

Abstract

Pediatric Health Information System data were used to establish a multi-center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD-9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD-9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML.

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Conflict of interest statement

Conflict of interest: Nothing to declare.

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