Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012 Dec;40(6):669-73.
doi: 10.1002/UOG.11170.

Association between body mass index and pregnancy outcome in a randomized trial of cerclage for short cervix

C K Farinelli  1 , D A Wing, J M Szychowski, J Owen, G Hankins, J D Iams, J S Sheffield, A Perez-Delboy, V Berghella, E R Guzman; Vaginal Ultrasound Trial Consortium
Collaborators, Affiliations
Randomized Controlled Trial

Association between body mass index and pregnancy outcome in a randomized trial of cerclage for short cervix

C K Farinelli et al. Ultrasound Obstet Gynecol. 2012 Dec.

Abstract

Objective: To evaluate whether increasing body mass index (BMI) alters the efficacy of ultrasound-directed cerclage in women with a history of preterm birth.

Methods: This was a planned secondary analysis of a multicenter trial in which women with a singleton gestation and prior spontaneous preterm birth (17 to 33 + 6 weeks' gestation) were screened for a short cervix by serial transvaginal ultrasound evaluations between 16 and 22 + 6 weeks. Women with a short cervix (cervical length < 25 mm) were randomly assigned to cerclage or not. Linear and logistic regression were used to assess the relationship between BMI and continuous and categorical variables, respectively.

Results: Overall, in the screened women (n = 986), BMI was not associated with cervical length (P = 0.68), gestational age at delivery (P = 0.12) or birth at < 35 weeks (P = 0.68). For the cerclage group (n = 148), BMI had no significant effect. For the no-cerclage group (n = 153), BMI was associated with a decrease in gestational age at delivery, with an estimated slope of - 0.14 weeks per kg/m(2) (P = 0.03; including adjustment for cervical length). This result was driven primarily by several women with BMI > 47 kg/m(2) .

Conclusion: In women at high risk for recurrent preterm birth, BMI was not associated with cervical length or gestational age at birth. BMI did not appear to adversely affect ultrasound-indicated cerclage.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Flowchart of Subjects
Figure 2:
Figure 2:
Relationship of Body Mass Index and Gestational Age at Delivery in Women Randomized to Not Receive a Cerclage
See this image and copyright information in PMC

References

    1. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and Trends in Obesity Among US Adults, 1999–2008. JAMA 2010; 303: 235–241. - PubMed
    1. Hamilton BE, Martin JA, Ventura SJ. Births: Preliminary data for 2008 Natl Vital Stat Rep; 58 (16). Hyattsville, MD: National Center for Health Statistics. Released April 6, 2010. - PubMed
    1. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371:75–84. - PMC - PubMed
    1. Spong CY. Prediction and prevention of recurrent spontaneous preterm birth. Obstet Gynecol 2007;110:405–415. - PubMed
    1. McManemy J, Cooke E, Amon E, Leet T. Recurrent risk for preterm delivery. Am J Obstet Gynecol 2007; 196:576.e1–576e.7. - PubMed

Publication types