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. 1979 Aug;17(7-8):683-92.
doi: 10.1007/BF00502126.

Expression of galactose-1-p-uridyltransferase in Chinese hamster x human galactosemia somatic cell hybrids

R S Sparkes, T Mohandas, M C Sparkes, J D Shulkin

Expression of galactose-1-p-uridyltransferase in Chinese hamster x human galactosemia somatic cell hybrids

R S Sparkes et al. Biochem Genet. 1979 Aug.

Abstract

Lymphocytes from a patient with classic galactosemia (GALT deficiency) were hybridized with a Chinese hamster cell line. Electrophoretic valuation of GALT in 31 independently derived interspecific hybrid clones failed to demonstrate expression of the human GALT gene even when human chromosome 9 was present. Possible mechanisms for this lack of expression are presented.

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References

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