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. 2013 Feb 1;62(2):204-7.
doi: 10.1097/QAI.0b013e31827ce536.

Impact of hepatitis C virus on HIV response to antiretroviral therapy in Nigeria

Oche Agbaji  1 , Chloe L Thio, Seema Meloni, Camilla Graham, Mohammed Muazu, Ladep Nimzing, John Idoko, Jean-Louis Sankalé, Ernest Ekong, Robert Murphy, Phyllis Kanki, Claudia Hawkins
Affiliations

Impact of hepatitis C virus on HIV response to antiretroviral therapy in Nigeria

Oche Agbaji et al. J Acquir Immune Defic Syndr. .

Abstract

The effect of hepatitis C virus (HCV) on antiretroviral therapy (ART) response in patients in sub-Saharan Africa is unknown. We studied 1431 HIV-infected ART initiators in Jos, Nigeria, of whom 6% were HCV coinfected. A similar proportion of HIV/HCV-coinfected and HIV-monoinfected patients achieved HIV RNA <400 copies per milliliter after 24 and 48 weeks of ART (P > 0.05). Hepatotoxicity was uncommon (0.8% and 0.33% at 24 and 48 weeks, respectively) but was more common in the HIV/HCV-coinfected group at 24 (adjusted odds ratio = 19.3; 95% confidence interval: 4.41 to 84.4) and 48 weeks (adjusted odds ratio = 56.7; 95% confidence interval: 5.03 to 636.92). HCV did not significantly impact ART response in this Nigerian cohort.

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Conflict of interest statement

Conflicts of Interest: All authors: No reported conflicts.

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