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Comment
. 2012 Dec 4;109(49):19882-3.
doi: 10.1073/pnas.1218953109. Epub 2012 Nov 29.

Leber hereditary optic neuropathy and oxidative stress

Yehong Zhuo  1 , Hongrong Luo, Kang Zhang
Affiliations
Comment

Leber hereditary optic neuropathy and oxidative stress

Yehong Zhuo et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
ROS produced through the process of oxidative phosphorylation by the electron transport chain in mitochondria. NADH dehydrogenase mutations of complex I may increase the leaking of electrons from the chain, leading to increased accumulation of ROS, oxidative stress, and RGC death.
See this image and copyright information in PMC

Comment on

  • Mouse mtDNA mutant model of Leber hereditary optic neuropathy.
    Lin CS, Sharpley MS, Fan W, Waymire KG, Sadun AA, Carelli V, Ross-Cisneros FN, Baciu P, Sung E, McManus MJ, Pan BX, Gil DW, Macgregor GR, Wallace DC. Lin CS, et al. Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20065-70. doi: 10.1073/pnas.1217113109. Epub 2012 Nov 5. Proc Natl Acad Sci U S A. 2012. PMID: 23129651 Free PMC article.

References

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    1. Huoponen K, Vilkki J, Aula P, Nikoskelainen EK, Savontaus ML. A new mtDNA mutation associated with Leber hereditary optic neuroretinopathy. Am J Hum Genet. 1991;48(6):1147–1153. - PMC - PubMed
    1. Wallace DC, et al. Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy. Science. 1988;242(4884):1427–1430. - PubMed

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