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. 2012 Dec 3;7(1):34.
doi: 10.1186/1750-9378-7-34.

Prevalence of human papillomavirus in the cervical epithelium of Mexican women: meta-analysis

Raúl Peralta-Rodríguez  1 , Pablo Romero-Morelos, Vanessa Villegas-Ruíz, Mónica Mendoza-Rodríguez, Keiko Taniguchi-Ponciano, Beatriz González-Yebra, Daniel Marrero-Rodríguez, Mauricio Salcedo
Affiliations

Prevalence of human papillomavirus in the cervical epithelium of Mexican women: meta-analysis

Raúl Peralta-Rodríguez et al. Infect Agent Cancer. .

Abstract

Background: Human Papillomavirus (HPV) in cervical epithelium has been identified as the main etiological factor in the developing of Cervical Cancer (CC), which has recently become a public health problem in Mexico. This finding has allowed for the development of vaccines that help prevent this infection. In the present study, we aimed to determine the prevalence and HPV type-distribution in Mexican women with CC, high-grade squamous intraepithelial lesion (HSIL), low-grade squamous intraepithelial lesion (LSIL), and Normal cytology (N) to estimate the impact of the HPV vaccines.

Methods: The PubMed database was used to identify and review all articles that reported data on HPV prevalence in CC, precursor lesions, and normal cytology of Mexican women.

Results: A total of 8,706 samples of the tissues of Mexican women were stratified according to diagnosis as follows: 499 for CC; 364 for HSIL; 1,425 for LSIL, and 6,418 for N. According to the results, the most prevalent genotypes are the following: HPV16 (63.1%), -18 (8.6%), -58, and -31 (5%) for CC; HPV-16 (28.3%), 58 (12.6%), 18 (7.4%), and 33 (6.5%) for HSIL; HPV-16 (13.1%), 33 (7.4%), 18 (4.2%), and 58 (2.6%) for LSIL, and HPV-16 (3.4%), 33 (2.1%), 18, and 58 (1.2%) for N.

Conclusions: Taken together, genotypes 58 and 31 (10%) are more common than type 18 (8.6%) in CC. Therefore, the inclusion of these two genotypes in a second-generation vaccine would provide optimal prevention of CC in Mexico.

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Figures

Figure 1
Figure 1
HPV prevalence in Mexican women. The HPV prevalence is expressed as percentage of all cases submitted to molecular detection of HPV. From 8,706 samples of Mexican women, 476/499 were positive for HPV and CC, 275/364 were positive for HPV and HSIL, 601/1,425 were positive for HPV and LSIL, 967/6,418 were positive for HPV and cytology normal.
Figure 2
Figure 2
A. HPV prevalence in women with normal cytology. B. HPV prevalence in women with LSIL. C. HPV prevalence in women with HSIL. D. HPV prevalence in women with CC. *: Low risk HPV (no oncogenic potential); **: high risk HPV (oncogenic potential); ***: HPV without sufficient epidemiological evidence to know their risk of oncogenesis (2).
Figure 3
Figure 3
Comparison of the most common HPV genotypes in each type of cervical lesion and normal cytology. HPV prevalence (types 16, 18, 58, 31, 33 and 45) in each type of cervical lesion and normal cytology. The genotypes analyzed correspond to the high risk and are most frequently found in cervical epithelium.
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