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. 2013 Oct;141(10):2187-91.
doi: 10.1017/S0950268812002695. Epub 2012 Dec 3.

Early high CMV seroprevalence in pregnant women from a population with a high rate of congenital infection

A Y Yamamoto  1 , R A C Castellucci, D C Aragon, M M Mussi-Pinhata
Affiliations

Early high CMV seroprevalence in pregnant women from a population with a high rate of congenital infection

A Y Yamamoto et al. Epidemiol Infect. 2013 Oct.

Abstract

Congenital cytomegalovirus (CMV) infection rates increase with maternal seroprevalence due to transmission from maternal non-primary infection. CMV seroprevalence estimates of pregnant women are needed for planning strategies against congenital CMV transmission. We aimed to determine the age-specific prevalence of serum antibodies for CMV in a representative age-stratified sample of unselected pregnant women from a Brazilian population. A total of 985 pregnant women, aged 12–46 years (median 24 years), were enrolled. Overall CMV seroprevalence was 97% (95% confidence interval 95.8–98.0), with age-specific (years) prevalence as follows: 12–19 (96.3%), 20–24 (97.7%), 25–29 (97.1%), and 30–46 (96.7%). CMV seroprevalence is almost universal (97%) and is found at similar levels in pregnant women of ages ranging from 12 to 46 years. Because high CMV seroprevalence is found even in women of a younger age in this population, this finding suggests that the majority of primary CMV infections occur early, in infancy or childhood. As a consequence, vaccines currently under development to prevent primary infection may not be a solution for the prevention of congenital CMV infection in this population.

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Figures

Fig. 1.
Fig. 1.
Boxplots of CMV antibody titres (AU/ml) after the natural logarithmical transformation according to age group.
See this image and copyright information in PMC

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