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. 2012 Nov 30;10(12):2741-8.
doi: 10.3390/md10122741.

Five new diterpenoids from an Okinawan soft coral, Cespitularia sp

Prodip K Roy  1 , Wilmar Maarisit, Michael C Roy, Junsei Taira, Katsuhiro Ueda
Affiliations

Five new diterpenoids from an Okinawan soft coral, Cespitularia sp

Prodip K Roy et al. Mar Drugs. .

Abstract

Five new diterpenoids 1-5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC₅₀ 5.85 μM), while these new diterpenoids 1-5 were much less active (IC₅₀ 28.2-91.4 μM).

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Figures

Figure 1
Figure 1
Structures of compounds 1–6.
Figure 2
Figure 2
Partial structures (a, b and c) of 1 based on COSY (bold line) and key HMBC correlations (arrows H/C).
See this image and copyright information in PMC

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