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Review
. 2012 Nov 5;4(11):2766-85.
doi: 10.3390/v4112766.

Immune responses and Lassa virus infection

Marion Russier  1 , Delphine Pannetier, Sylvain Baize
Affiliations
Review

Immune responses and Lassa virus infection

Marion Russier et al. Viruses. .

Abstract

Lassa fever is a hemorrhagic fever endemic to West Africa and caused by Lassa virus, an Old World arenavirus. It may be fatal, but most patients recover from acute disease and some experience asymptomatic infection. The immune mechanisms associated with these different outcomes have not yet been fully elucidated, but considerable progress has recently been made, through the use of in vitro human models and nonhuman primates, the only relevant animal model that mimics the pathophysiology and immune responses induced in patients. We discuss here the roles of the various components of the innate and adaptive immune systems in Lassa virus infection and in the control of viral replication and pathogenesis.

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Figures

Figure 1
Figure 1
Comparison of the responses induced in vitro by LASV (a) and MOPV (b) in human cells (adapted from references [20,21,39,44,45,80,93])
See this image and copyright information in PMC

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