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Review
. 2012 Oct 18;13(10):13414-37.
doi: 10.3390/ijms131013414.

The role of microRNAs in breast cancer migration, invasion and metastasis

Joy Tang  1 , Aamir Ahmad, Fazlul H Sarkar
Affiliations
Review

The role of microRNAs in breast cancer migration, invasion and metastasis

Joy Tang et al. Int J Mol Sci. .

Abstract

MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been implicated in several human cancers, including breast cancer. miRNAs are known to regulate cell cycle and development, and thus may serve as useful targets for exploration in anticancer therapeutics. The link between altered miRNA signatures and breast cancer development and metastasis can be observed either through the loss of tumor suppressor miRNAs, such as let-7s, miR-30a/31/34a/125s/200s/203/205/206/342 or the overexpression of oncogenic miRNAs, such as miR-10b/21/135a/155/221/222/224/373/520c in breast cancer cells. Some of these miRNAs have also been validated in tumor specimens of breast cancer patients, underscoring their potential roles in diagnostics, as well as targets for novel therapeutics for breast cancer. In this review article, we will provide an overview and update of our current understanding of the mode of action of several of these well characterized miRNAs in breast cancer models. Therefore, better understanding of the gene networks orchestrated by these miRNAs may help exploit the full potential of miRNAs in regards to cancer diagnosis, treatment, and therapeutics.

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Figures

Figure 1
Figure 1
Venn diagram showing an overlapping role of several miRNAs in breast cancer migration, invasion and metastasis.
See this image and copyright information in PMC

References

    1. Croce C.M., Calin G.A. miRNAs, cancer, and stem cell division. Cell. 2005;122:6–7. - PubMed
    1. Fabian M.R., Sonenberg N. The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC. Nat. Struct. Mol. Biol. 2012;19:586–593. - PubMed
    1. Ahmad A., Ali A.S., Ali S., Wang Z., Kong D., Sarkar F.H. MicroRNAs: Targets of Interest in Breast Cancer Research. In: Mulligan J.A., editor. MicroRNA: Expression, Detection and Therapeutic Strategies. Nova Science Publishers Inc; Hauppauge, NY, USA: 2011. pp. 59–78.
    1. Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843–854. - PubMed
    1. Garzon R., Fabbri M., Cimmino A., Calin G.A., Croce C.M. MicroRNA expression and function in cancer. Trends Mol. Med. 2006;12:580–587. - PubMed

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