Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;4(4):617-620.
doi: 10.3892/ol.2012.792. Epub 2012 Jul 9.

Specific organ metastases and survival in small cell lung cancer

Kensuke Nakazawa  1 , Koichi Kurishima, Tomohiro Tamura, Katsunori Kagohashi, Hiroichi Ishikawa, Hiroaki Satoh, Nobuyuki Hizawa
Affiliations

Specific organ metastases and survival in small cell lung cancer

Kensuke Nakazawa et al. Oncol Lett. 2012 Oct.

Abstract

The aim of our retrospective study was to evaluate the clinicopathological features associated with distant metastasis from small cell lung cancer (SCLC). We reviewed patients diagnosed with SCLC metastasis at the time of presentation between 1999 and 2010. Among the consecutive 251 SCLC patients diagnosed, 152 (60.6%) patients had distant metastasis, of which 20.3, 18.3, 15.5, 10.0 and 6.0% of patients had liver, bone, brain, lung and adrenal gland metastasis, respectively. In a multivariate analysis using Cox's proportional hazards model, we identified that liver, bone and brain metastasis as well as the presence of pleural and/or pericardial fluids were unfavorable prognostic factors. However, lung, adrenal gland and extrathoracic lymph node metastasis were not statistically significant prognostic factors. With regard to the treatment of SCLC patients, particularly those with liver, bone and brain metastasis or pleural and/or pericardial fluids, we should take the metastasizing organs into consideration.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Comparison of survival between patients without metastasis, patients with one metastatic site and patients with two or more metastatic sites.
See this image and copyright information in PMC

References

    1. Ferraldeschi R, Baka S, Jyoti B, Faivre-Finn C, Thatcher N, Lorigan P. Modern management of small-cell lung cancer. Drugs. 2007;67:2135–2152. - PubMed
    1. Foster NR, Mandrekar SJ, Schild SE, et al. Prognostic factors differ by tumor stage for small cell lung cancer: a pooled analysis of North Central Cancer Treatment Group trials. Cancer. 2009;115:2721–2731. - PMC - PubMed
    1. Travis W, Brambilla E, Muller-Hermelink H, Harris C, editors. Pathology and Genetics World Health Organisation Classification of Tumours. IARC Press; Lyon: 2004. Tumours of the lung, pleura, thymus and heart.
    1. Zelen M. Keynote address on biostatistics and data retrieval. Cancer Chemother Rep 3. 1973;4:31–42. - PubMed
    1. Shepherd FA, Ginsberg RJ, Haddad R, et al. Importance of clinical staging in limited small-cell lung cancer: a valuable system to separate prognostic subgroups. The University of Toronto Lung Oncology Group. J Clin Oncol. 1993;11:1592–1597. - PubMed

LinkOut - more resources