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Comparative Study
. 1990 Apr;87(7):2628-32.
doi: 10.1073/pnas.87.7.2628.

Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor

G Conn  1 , M L Bayne, D D Soderman, P W Kwok, K A Sullivan, T M Palisi, D A Hope, K A Thomas
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Comparative Study

Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor

G Conn et al. Proc Natl Acad Sci U S A. 1990 Apr.

Abstract

Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.

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References

    1. Mol Cell Biol. 1987 Oct;7(10):3527-37 - PubMed
    1. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1323-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1492-6 - PubMed
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