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Comment
. 2013 Apr;23(4):449-51.
doi: 10.1038/cr.2012.169. Epub 2012 Dec 4.

LncRNAs have a say in protein translation

Maite Huarte  1
Affiliations
Comment

LncRNAs have a say in protein translation

Maite Huarte. Cell Res. 2013 Apr.

Abstract

In a recent paper published in Nature, Carrieri et al. have identified in mouse a neuron-specific antisense lncRNA transcribed in the opposite strand of Uchl1 mRNA. Antisense Uchl1 specifically promotes the translation of UCHL1 under rapamycin treatment. To do so, the lncRNA only requires a SINEB2 repeat and a small region with sequence complementarity to the regulated mRNA.

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Figures

Figure 1
Figure 1
Effect of antisense Uchl1 on UCHL1 protein expression. Under basal conditions (left), antisense Uchl1 is mostly retained in the nucleus of mouse dopaminergic neurons, while Uchl1 mRNA is exported to the cytoplasm. Under rapamycin treatment (right), antisense Uchl1 is exported to the cytoplasm, Uchl1 mRNA is relocated to polyribosomes and UCHL1 protein levels increase.
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