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Review
. 2012 Dec:Chapter 10:10.1.1-10.1.16.
doi: 10.1002/0471143030.cb1001s57.

Overview of extracellular matrix

Robert P Mecham  1
Affiliations
Review

Overview of extracellular matrix

Robert P Mecham. Curr Protoc Cell Biol. 2012 Dec.

Abstract

The extracellular matrix provides an environment for cells. It is produced, assembled, and modified by cells and in turn, it modifies the functions and behavior of the cells it encounters. The molecules that make up the matrix are diverse in both structure and function. This well-illustrated unit provides an introduction to the structure and function of the major components of the extracellular matrix and serves as a background for the other units in the chapter, which include protocols for isolation and analysis of individual components.

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References

Literature Cited

    1. Adams, J.C. and Lawler, J. 2011. The thrombospondins. Cold Spring Harbor Perspect. Biol. 3:a009712.
    1. Aumailley, M., Bruckner-Tuderman, L., Carter, W.G., Deutzmann, R., Edgar, D., Ekblom, P., Engel, J., Engvall, E., Hohenester, E., Jones, J.C., Kleinman, H.K., Marinkovich, M.P., Martin, G.R., Mayer, U., Meneguzzi, G., Miner, J.H., Miyazaki, K., Patarroyo, M., Paulsson, M., Quaranta, V., Sanes, J.R., Sasaki, T., Sekiguchi, K., Sorokin, L.M., Talts, J.F., Tryggvason, K., Uitto, J., Virtanen, I., von der Mark, K., Wewer, U.M., Yamada, Y., and Yurchenco, P.D. 2005. A simplified laminin nomenclature. Matrix Biol. 24:326-332.
    1. Aumailley, M., Gimond, C., and Rousselle, P. 1996. Integrin-mediated cellular interactions with laminins. In The Laminins (P. Ekblom and R. Timpl, eds.) pp. 127-158. Harwood Academic Publishers, New York.
    1. Baldock, C., Sherratt, M.J., Shuttleworth, C.A., and Kielty, C.M. 2003. The supramolecular organization of collagen VI microfibrils. J. Mol. Biol. 330:297-307.
    1. Beck, K., Hunter, I., and Engel, J. 1990. Structure and function of laminin: Anatomy of a multidomain glycoprotein. FASEB J. 4:148-160.

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