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. 2013 Jan 21;49(6):564-6.
doi: 10.1039/c2cc37460a. Epub 2012 Dec 4.

Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

Graeme J Stasiuk  1 , Helen Smith, Marzena Wylezinska-Arridge, Jordi L Tremoleda, William Trigg, Sajinder Kaur Luthra, Veronique Morisson Iveson, Felicity N E Gavins, Nicholas J Long
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Free article

Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

Graeme J Stasiuk et al. Chem Commun (Camb). .
Free article

Abstract

Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(III) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.

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