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. 2013 Jan;88(1):37-42.
doi: 10.4269/ajtmh.2012.12-0359. Epub 2012 Dec 3.

Plasmodium falciparum Na+/H+ exchanger (pfnhe-1) genetic polymorphism in Indian Ocean malaria-endemic areas

Valérie Andriantsoanirina  1 , Nimol Khim, Arsene Ratsimbasoa, Benoit Witkowski, Christophe Benedet, Lydie Canier, Christiane Bouchier, Magali Tichit, Rémy Durand, Didier Ménard
Affiliations

Plasmodium falciparum Na+/H+ exchanger (pfnhe-1) genetic polymorphism in Indian Ocean malaria-endemic areas

Valérie Andriantsoanirina et al. Am J Trop Med Hyg. 2013 Jan.

Abstract

To date, 11 studies conducted in different countries to test the association between Plasmodium falciparum Na(+)/H(+) exchanger gene (pfnhe-1; PF13_0019) polymorphisms and in vitro susceptibility to quinine have generated conflicting data. In this context and to extend our knowledge of the genetic polymorphism of Pfnhe gene, we have sequenced the ms4760 locus from 595 isolates collected in the Comoros (N = 250; an area with a high prevalence of chloroquine and sulfadoxine-pyrimethamine resistance) and Madagascar (N = 345; a low drug-resistance area). Among them, 29 different alleles were observed, including 8 (27%) alleles not previously described. Isolates from the Comoros showed more repeats in block II (DNNND), which some studies have found to be positively associated with in vitro resistance to quinine, compared with isolates from Madagascar. Additional studies are required to better define the mechanisms underlying quinine resistance, which involve multiple gene interactions.

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Figures

Figure 1.
Figure 1.
Samples collection sites in the Comoros Islands and Madagascar from 2006 to 2007.
Figure 2.
Figure 2.
Amino acid alignment of 29 ms4760 haplotypes found in the Comoros Islands and Madagascar from 2006 to 2007.
See this image and copyright information in PMC

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