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Comment
. 2013 Jan 15;19(2):311-3.
doi: 10.1158/1078-0432.CCR-12-3313. Epub 2012 Dec 3.

Targeted isotretinoin in neuroblastoma: kinetics, genetics, or absorption

Katherine K Matthay  1
Affiliations
Comment

Targeted isotretinoin in neuroblastoma: kinetics, genetics, or absorption

Katherine K Matthay. Clin Cancer Res. .

Abstract

Isotretinoin (13-cis-retinoic acid; 13-cisRA) has been shown to significantly improve survival for children with high-risk neuroblastoma. Pharmacokinetics of isotretinoin may be negatively affected by the mode of drug administration and the dosing formula.

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Conflict of interest statement

I have no conflicts of interest

Figures

Figure
Figure
Postulated effect of increasing 13-cisRA plasma levels on outcome for children with neuroblastoma. The significant factors for raising Cmax plasma levels ≥ 2 µM were the ability to swallow the capsules whole rather than extraction of the contents, and the dosing by body surface area rather than conversion to weight based dosing. No significance was found to age, gender, weight, BSA, ALT, bilirubin, GFR, creatinine, type of food mixed with capsule contents, use of NG tube, or the pharmacogenetics examined.
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References

    1. Veal GJ, Errington J, Rowbotham SE, Illingworth NA, Malik G, Cole M, et al. Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma. Clinical Cancer Research. 2012 in press. - PMC - PubMed
    1. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis- retinoic acid. Children's Cancer Group. N Engl J Med. 1999;341:1165–73. - PubMed
    1. Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363:1324–34. - PMC - PubMed
    1. Reynolds CP, Kane DJ, Einhorn PA, Matthay KK, Crouse VL, Wilbur JR, et al. Response of neuroblastoma to retinoic acid in vitro and in vivo. Prog Clin Biol Res. 1991;366:203–11. - PubMed
    1. Khan AA, Villablanca JG, Reynolds CP, Avramis VI. Pharmacokinetic studies of 13-cis-retinoic acid in pediatric patients with neuroblastoma following bone marrow transplantation. Cancer Chemother Pharmacol. 1996;39:34–41. - PubMed

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