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Review
. 2012 Dec 1;4(12):a011148.
doi: 10.1101/cshperspect.a011148.

The cyclic AMP pathway

Affiliations
Review

The cyclic AMP pathway

Paolo Sassone-Corsi. Cold Spring Harb Perspect Biol. .

Abstract

cAMP was the first second messenger to be identified. Its three main effectors are PKA (which phosphorylates numerous metabolic enzymes), EPAC (a guanine-nucleotide-exchange factor), and cyclic-nucleotide-gated ion channels.

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Figures

Figure 1.
Figure 1.
PKA regulation.
Figure 2.
Figure 2.
The cAMP/PKA pathway.

References

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    1. Mayr B, Montminy M 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2: 599–609 - PubMed

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