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. 2012:8:1884-9.
doi: 10.3762/bjoc.8.217. Epub 2012 Nov 5.

Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

Chao Yang  1 , Yutian Shao, Kang Li, Wujiong Xia
Affiliations

Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

Chao Yang et al. Beilstein J Org Chem. 2012.

Abstract

A new selaginellin named selaginellin O (1), along with three other known selaginellins (2-4) were isolated from Selaginella tamariscina (Beauv.) Spring. On the basis of spectroscopic analysis, the structure of selaginellin O was demonstrated to be 4-[(4'-hydroxy-4-formyl-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one. Compound 1, 2 and 3 exhibited appreciable cytotoxic activity against cultured HeLa cells (human cervical carcinoma cells), as well as significant antioxidant activity.

Keywords: Selaginella tamariscina; antioxidant; cytotoxicity; selaginellin.

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Figures

Figure 1
Figure 1
Structures of selaginellins from S. tamariscina.
Figure 2
Figure 2
Key HMBC correlations of compound 1.
See this image and copyright information in PMC

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