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. 2012;6(11):e1937.
doi: 10.1371/journal.pntd.0001937. Epub 2012 Nov 29.

Considerations in the design of clinical trials to test novel entomological approaches to dengue control

Marcel Wolbers  1 , Immo Kleinschmidt, Cameron P Simmons, Christl A Donnelly
Affiliations

Considerations in the design of clinical trials to test novel entomological approaches to dengue control

Marcel Wolbers et al. PLoS Negl Trop Dis. 2012.
No abstract available

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Conflict of interest statement

Cameron Simmons is an investigator in the Eliminate Dengue Project, which aims to use Wolbachia-infected Aedes aegypti mosquitoes to reduce dengue transmission.

Figures

Figure 1
Figure 1. Sample size estimates for a PCRT or a SWCRT.
Total number of clusters required for a PCRT (black lines) or a SWCRT (blue lines) depending on the size of the intervention effect. Solid lines correspond to 90% power, dashed lines to 80% power. Simulations are based on parameters determined from the Kamphaeng Phet dengue cohort (Thailand) (described in [10]) with three time periods each of 1-year duration, a surveillance cohort of 100 children in each cluster, and a two-sided significance level of 5%.
See this image and copyright information in PMC

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