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. 2012:2012:176298.
doi: 10.1155/2012/176298. Epub 2012 Oct 17.

Psoriatic arthritis: an update

Peter Lloyd  1 , Caitriona Ryan, Alan Menter
Affiliations

Psoriatic arthritis: an update

Peter Lloyd et al. Arthritis. 2012.

Abstract

Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Recent findings have furthered our understanding of the complex pathophysiology of PsA. There have been major advances in the identification of genes associated with joint involvement but not with cutaneous disease alone. The elucidation of key immunologic pathways has allowed the development of novel targeted therapies that are in the research pipeline. Currently, good screening tests and biomarkers to diagnose early PsA and to guide therapy are limited. In this paper, we present recent findings with regard to the immunopathogenesis and genetics of PsA, biomarkers, and screening tools and review the targeted therapies currently in clinical trials.

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References

    1. Gottlieb A, Korman NJ, Gordon KB, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: section 2. psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. Journal of the American Academy of Dermatology. 2008;58(5):851–864. - PubMed
    1. Gladman DD, Antoni C, Mease P, Clegg DO, Nash O. Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Annals of the Rheumatic Diseases. 2005;64(supplement 2):ii14–ii17. - PMC - PubMed
    1. Klippel JH. Primer on the Rheumatic Diseases. 13th edition. New York, NY, USA: Springer; 2008.
    1. Naredo E, Möller I, de Miguel E, et al. High prevalence of ultrasonographic synovitis and enthesopathy in patients with psoriasis without psoriatic arthritis: a prospective case-control study. Rheumatology. 2011;50(10):1838–1848. - PubMed
    1. Wittkowski KM, Leonardi C, Gottlieb A, et al. Clinical symptoms of skin, nails, and joints manifest independently in patients with concomitant psoriasis and psoriatic arthritis. PLoS ONE. 2011;6(6)e20279 - PMC - PubMed