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. 1990 Mar 30;247(4950):1589-91.
doi: 10.1126/science.2321020.

Endogenous cholecystokinin reduces feeding in young rats

A Weller  1 , G P Smith, J Gibbs
Affiliations

Endogenous cholecystokinin reduces feeding in young rats

A Weller et al. Science. .

Abstract

The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.

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