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Meta-Analysis
. 2013 Nov;7(6):1017-32.
doi: 10.1111/irv.12036. Epub 2012 Dec 5.

Burden of influenza in Latin America and the Caribbean: a systematic review and meta-analysis

Vilma Savy  1 , Agustín Ciapponi, Ariel Bardach, Demián Glujovsky, Patricia Aruj, Agustina Mazzoni, Luz Gibbons, Eduardo Ortega-Barría, Rómulo E Colindres
Affiliations
Meta-Analysis

Burden of influenza in Latin America and the Caribbean: a systematic review and meta-analysis

Vilma Savy et al. Influenza Other Respir Viruses. 2013 Nov.

Abstract

Objective: Influenza causes severe morbidity and mortality. This systematic review aimed to assess the incidence, etiology, and resource usage for influenza in Latin America and the Caribbean.

Design: Meta-analytic systematic review. Arcsine transformations and DerSimonian Laird random effects model were used for meta-analyses.

Setting: A literature search from 1980 to 2008 in MEDLINE, Cochrane Library, EMBASE, LILACS, Ministries of Health, PAHO, proceedings, reference lists, and consulting experts.

Sample: We identified 1092 references, of which 31 were finally included, in addition to influenza surveillance reports. We also used information from the 10 reports from the collaborative group for epidemiological surveillance of influenza and other respiratory virus (GROG), and information retrieved from the WHO global flu database FLUNET.

Main outcome measures: Incidence, percentage of influenza specimens out of the total received by influenza centers and resource-use outcomes.

Results: A total of 483 130 specimens of patients with influenza were analyzed. Meta-analysis showed an annual rate of 36 080 (95%CI 28 550 43 610) influenza-like illness per 100 000 persons-years. The percentage of influenza out of total specimens received by influenza centers ranged between 4.66% and 15.42%, with type A the most prevalent, and A subtype H3 predominating. The mean length of stay at hospital due to influenza ranged between 5.8 12.9 days, total workdays lost due to influenza-like illnesses were 17 150 days, and the mean direct cost of hospitalization was US$575 per laboratory-confirmed influenza case.

Conclusions: Our data show that seasonal influenza imposes a high morbidity and economic burden to the region. However, the vaccine-uptake rate has been low in this region. Population-based cohort studies are required to improve the knowledge about incidence and resource utilization, which would inform healthcare authorities for decision making.

Keywords: Burden of disease; Latin America & Caribbean; costs; epidemiology; influenza; influenza-like illness; use of resources.

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Figures

Figure 1
Figure 1
Flow diagram for study selection.
Figure 2
Figure 2
Incidence of Influenza‐like illness.
Figure 3
Figure 3
Percentage of influenza in samples by country and year: initial (1999) and final (2008) reports.
See this image and copyright information in PMC

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References

    1. Morales A, Martinez MM, Tasset‐Tisseau A, Rey E, Baron‐Papillon F, Follet A. Costs and benefits of influenza vaccination and work productivity in a Colombian company from the employer’s perspective. Value Health 2004; 7:433–441. - PubMed
    1. Coelho MC, Tsuchiya LRRV, Nogueira MB et al. Impact of respiratory infections by influenza viruses A and B in pediatrics patients from Federal University of Parana, Brazil. Braz J Infect Dis 2007; 11:220–223. - PubMed
    1. Neuzil KM, Zhu Y, Griffin MR et al. Burden of interpandemic influenza in children younger than 5 years: a 25, year prospective study. J Infect Dis 2002; 185:147–152. - PubMed
    1. Dayan GH, Nguyen VH, Debbag R, Gomez R, Wood SC. Cost‐effectiveness of influenza vaccination in high‐risk children in Argentina. Vaccine 2001; 19:4204–4213. - PubMed
    1. Glezen WP, Taber LH, Frank AL, Gruber WC, Piedra PA. Influenza virus infections in infants. Pediatr Infect Dis J 1997; 16:1065–1068. - PubMed

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