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. 2013 Sep;7(5):827-32.
doi: 10.1111/irv.12063. Epub 2012 Dec 5.

Retrospective serological survey of influenza viruses in backyard pigs from Mexico City

Manuel Saavedra-Montañez  1 , Víctor Carrera-Aguirre, Héctor Castillo-Juárez, Francisco Rivera-Benitez, Karina Rosas-Estrada, Evelyn Pulido-Camarillo, Carmen Mercado-García, Rosalba Carreón-Nápoles, Mario Haro-Tirado, Dora P Rosete, Carlos Cabello, María E Manjarrez, Iván Sánchez-Betancourt, Humberto Ramírez-Mendoza
Affiliations

Retrospective serological survey of influenza viruses in backyard pigs from Mexico City

Manuel Saavedra-Montañez et al. Influenza Other Respir Viruses. 2013 Sep.

Abstract

Background: In the present study, we analyzed the presence of antibodies to four different influenza viruses (pH1N1, hH1N1, swH1N1, and swH3N2) in the sera of 2094 backyard pigs from Mexico City. The sera were obtained between 2000 and 2009.

Objectives: The aim of this study was to perform a retrospective analysis of the 2000-2009 period to determine the seroprevalence of antibodies against pH1N1, hH1N1, swH1N1, and swH3N2 viruses in sera obtained from backyard pigs in Mexico City.

Methods: Antibody detection was conducted with hemagglutination inhibition assay (HI) using four influenza viruses. We used linear regression to analyze the tendency of antibody serum titers throughout the aforementioned span.

Results: We observed that the antibody titers for the pH1N1, swH1N1, and swH3N2 viruses tended to diminish over the study period, whereas the antibodies to hH1N1 remained at low prevalence for the duration of the years analyzed in this study. A non-significant correlation (P > 0.05) between antibody titers for pH1N1 and swH1N1 viruses was observed (0.04). It contrasts with the significance of the correlation (0.43) observed between the swH1N1 and swH3N2 viruses (P < 0.01).

Conclusions: Our findings showed no cross-antigenicity in the antibody response against the same subtype. Antibodies against pH1N1 virus were observed throughout the 10-year study span, implying that annual strains shared some common features with the pH1N1 virus since 2000, which would then be capable of supporting the ongoing presence of these antibodies.

Keywords: backyard swine systems; influenza viruses; seroprevalence pH1N1-hH3N2-swH1N1-swH3N2.

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Figures

Figure 1
Figure 1
Sampling sites in Mexico City. Stars represent the regions from which pig sera were obtained (modified from INEGI, 2005; http://cuentame.inegi.org.mx/mapas/pdf/entidades/div_municipal/dfdeleg.pdf).
Figure 2
Figure 2
Percentages of seropositivity against four different influenza viruses in backyard pigs during the period 2000–2009.
Figure 3
Figure 3
Mean value for antibody titers against four different influenza viruses along a 10‐year period.
See this image and copyright information in PMC

References

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