Neuroimaging in the early diagnosis of neurodegenerative disease

doi:10.1186/2047-9158-1-5

. 2012 Jan 13;1(1):5.

doi: 10.1186/2047-9158-1-5.

Neuroimaging in the early diagnosis of neurodegenerative disease

A Jon Stoessl¹

Affiliations

Affiliation

¹ Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, 2221 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada. jstoessl@mail.ubc.ca.

PMID: 23211024
PMCID: PMC3506998
DOI: 10.1186/2047-9158-1-5

Neuroimaging in the early diagnosis of neurodegenerative disease

A Jon Stoessl. Transl Neurodegener. 2012.

. 2012 Jan 13;1(1):5.

doi: 10.1186/2047-9158-1-5.

Author

A Jon Stoessl¹

Affiliation

¹ Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, 2221 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada. jstoessl@mail.ubc.ca.

PMID: 23211024
PMCID: PMC3506998
DOI: 10.1186/2047-9158-1-5

Abstract

Functional imaging may be useful for both the early diagnosis as well as preclinical detection of neurodegenerative disease. Additionally, while structural imaging has traditionally been regarded as a tool to exclude alternate diagnoses, recent advances in magnetic resonance show promise for greater diagnostic specificity. The role of MR and radionuclide imaging in early diagnosis and preclinical detection of dementia and parkinsonism are reviewed here.

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References

1. Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E. et al.Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21(10):718–79. doi: 10.1016/j.euroneuro.2011.08.008. - DOI - PubMed
1. Benamer TS, Patterson J, Grosset DG, Booij J, de Bruin K, van Royen E. et al.Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord. 2000;15(3):503–10. doi: 10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V. - DOI - PubMed
1. Marek K, Seibyl J, Shoulson I, Holloway R, Kieburtz K, McDermott M. et al.Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA. 2002;287(13):1653–61. doi: 10.1001/jama.287.13.1653. - DOI - PubMed
1. Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C. et al.Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann Neurol. 2003;54(1):93–101. doi: 10.1002/ana.10609. - DOI - PubMed
1. Schneider SA, Edwards MJ, Mir P, Cordivari C, Hooker J, Dickson J. et al.Patients with adult-onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs) Mov Disord. 2007;22(15):2210–5. doi: 10.1002/mds.21685. - DOI - PubMed

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[1] Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E. et al.Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21(10):718–79. doi: 10.1016/j.euroneuro.2011.08.008. - DOI - PubMed

[2] Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E. et al.Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21(10):718–79. doi: 10.1016/j.euroneuro.2011.08.008. - DOI - PubMed

[3] Benamer TS, Patterson J, Grosset DG, Booij J, de Bruin K, van Royen E. et al.Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord. 2000;15(3):503–10. doi: 10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V. - DOI - PubMed

[4] Benamer TS, Patterson J, Grosset DG, Booij J, de Bruin K, van Royen E. et al.Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord. 2000;15(3):503–10. doi: 10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V. - DOI - PubMed

[5] Marek K, Seibyl J, Shoulson I, Holloway R, Kieburtz K, McDermott M. et al.Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA. 2002;287(13):1653–61. doi: 10.1001/jama.287.13.1653. - DOI - PubMed

[6] Marek K, Seibyl J, Shoulson I, Holloway R, Kieburtz K, McDermott M. et al.Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA. 2002;287(13):1653–61. doi: 10.1001/jama.287.13.1653. - DOI - PubMed

[7] Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C. et al.Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann Neurol. 2003;54(1):93–101. doi: 10.1002/ana.10609. - DOI - PubMed

[8] Whone AL, Watts RL, Stoessl AJ, Davis M, Reske S, Nahmias C. et al.Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann Neurol. 2003;54(1):93–101. doi: 10.1002/ana.10609. - DOI - PubMed

[9] Schneider SA, Edwards MJ, Mir P, Cordivari C, Hooker J, Dickson J. et al.Patients with adult-onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs) Mov Disord. 2007;22(15):2210–5. doi: 10.1002/mds.21685. - DOI - PubMed

[10] Schneider SA, Edwards MJ, Mir P, Cordivari C, Hooker J, Dickson J. et al.Patients with adult-onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs) Mov Disord. 2007;22(15):2210–5. doi: 10.1002/mds.21685. - DOI - PubMed

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Neuroimaging in the early diagnosis of neurodegenerative disease

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Neuroimaging in the early diagnosis of neurodegenerative disease

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