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. 2013 Mar 1;99(3):790-5.
doi: 10.1016/j.fertnstert.2012.11.013. Epub 2012 Dec 1.

In utero exposures and endometriosis: the Endometriosis, Natural History, Disease, Outcome (ENDO) Study

Erin Foran Wolff  1 , Liping Sun, Mary L Hediger, Rajeshwari Sundaram, C Matthew Peterson, Zhen Chen, Germaine M Buck Louis
Affiliations

In utero exposures and endometriosis: the Endometriosis, Natural History, Disease, Outcome (ENDO) Study

Erin Foran Wolff et al. Fertil Steril. .

Abstract

Objective: To assess in utero exposures and the odds of an endometriosis diagnosis.

Design: Matched cohort design.

Setting: Fourteen participating clinical centers in geographically defined areas in Utah and California.

Patient(s): Operative cohort comprised 473 women undergoing laparoscopy/laparotomy, and an age- and residence-matched population cohort comprising 127 women undergoing pelvic magnetic resonance imaging (MRI), 2007-2009.

Intervention(s): None.

Main outcome measure(s): Women completed standardized interviews before surgery or MRI regarding in utero exposures: mothers' lifestyle during the index pregnancy, and the index woman's gestation and birth size. Endometriosis was defined as visually confirmed disease in the operative cohort, and MRI visualized disease in the population cohort. The odds of an endometriosis diagnosis and corresponding 95% confidence intervals (CI) were estimated for each exposure by cohort using logistic regression and adjusting for current smoking, age at menarche, body mass index, and study site.

Result(s): Endometriosis was diagnosed in 41% and 11% of women in the operative and population cohorts, respectively. In the primary analysis, adjust odds ratios (AORs) were elevated for maternal vitamin usage (1.27; 95% CI, 0.85-1.91), maternal cigarette smoking (1.16; 95% CI = 0.61-2.24), and low birth weight (1.1; 95% CI, 0.92-1.32). Reduced odds were observed for maternal usage of caffeine (0.99; 95% CI, 0.64-1.54), alcohol (0.82; 95% CI, 0.35-1.94), paternal cigarette smoking (0.72; 95% CI, 0.43-1.19), and preterm delivery (0.98; 95% CI, 0.47-2.03). Sensitivity analyses mostly upheld the primary results except for a decreased AOR for preterm birth (0.41; 95% CI, 0.18-0.94) when restricting to visualized and histologically confirmed endometriosis in the operative cohort.

Conclusion(s): In utero exposures were not statistically significantly associated with the odds of an endometriosis diagnosis in either cohort.

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References

    1. Barker DJ. The fetal and infant origins of adult disease. BMJ. 1990;301:1111. - PMC - PubMed
    1. Gluckman PD, Hanson MA, Mitchell MD. Developmental origins of health and disease: reducing the burden of chronic disease in the next generation. Genome Med. 2010;2:14. - PMC - PubMed
    1. Daxinger L, Whitelaw E. Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet. 2012 - PubMed
    1. Heindel JJ. Role of exposure to environmental chemicals in the developmental basis of reproductive disease and dysfunction. Semin Reprod Med. 2006;24:168–77. - PubMed
    1. Baird DD, Newbold R. Prenatal diethylstilbestrol (DES) exposure is associated with uterine leiomyoma development. Reprod Toxicol. 2005;20:81–4. - PubMed

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