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Randomized Controlled Trial
. 2013 Apr;20(4):443-7.
doi: 10.1097/gme.0b013e318275025e.

Effect of soy isoflavone supplementation on menopausal quality of life

Paula Amato  1 , Ronald L Young, Francene M Steinberg, Michael J Murray, Richard D Lewis, Margaret A Cramer, Stephen Barnes, Kenneth J Ellis, Roman J Shypailo, Joe Kennard Fraley, Karen L Konzelmann, Joan G Fischer, Colette LaSalle, Elliot O'Brian Smith, William W Wong
Affiliations
Randomized Controlled Trial

Effect of soy isoflavone supplementation on menopausal quality of life

Paula Amato et al. Menopause. 2013 Apr.

Abstract

Objective: The purpose of this study was to assess the effect of soy isoflavone supplementation on quality of life in postmenopausal women.

Methods: A multicenter, randomized, double-blind, placebo-controlled 24-month trial was conducted to assess the effect of 80 or 120 mg of daily aglycone hypocotyl soy isoflavone supplementation on quality of life in 403 postmenopausal women using a validated Menopause-Specific Quality of Life questionnaire.

Results: Menopause-Specific Quality of Life domain scores at 1 year and 2 years were similar to baseline. There were no differences in domain scores among treatment groups.

Conclusions: Soy isoflavone supplementation offers no benefit to quality of life in postmenopausal women.

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