Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jan;93(1):78-85.
doi: 10.1038/clpt.2012.198. Epub 2012 Dec 5.

Emerging target-based paradigms to prevent and treat migraine

S D Silberstein  1
Affiliations
Review

Emerging target-based paradigms to prevent and treat migraine

S D Silberstein. Clin Pharmacol Ther. 2013 Jan.

Abstract

Migraine is a primary brain disorder resulting from altered modulation of normal sensory stimuli and trigeminal nerve dysfunction. The second edition of the International Classification of Headache Disorders (ICHD-2) defines seven subtypes of migraine. Migraine treatment can be acute or preventive. New targeted therapies include 5-HT(1F) receptor agonists, calcitonin gene-related peptide (CGRP) antagonists, nitric oxide synthetase inhibitors, and ion channel antagonists. A recent development is the creation of antibodies to CGRP and its receptor for migraine prevention.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources