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. 2013 Feb 6;105(3):237-43.
doi: 10.1093/jnci/djs486. Epub 2012 Dec 3.

Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations

Christopher A Haiman  1 , Daniel O Stram, Andrew J Vickers, Lynne R Wilkens, Katharina Braun, Camilla Valtonen-André, Mari Peltola, Kim Pettersson, Kevin M Waters, Loic Le Marchand, Laurence N Kolonel, Brian E Henderson, Hans Lilja
Affiliations

Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations

Christopher A Haiman et al. J Natl Cancer Inst. .

Abstract

Background: A common genetic variant (rs10993994) in the 5' region of the gene encoding β-microseminoprotein (MSP) is associated with circulating levels of MSP and prostate cancer risk. Whether MSP levels are predictive of prostate cancer risk has not been evaluated.

Methods: We investigated the prospective relationship between circulating plasma levels of MSP and prostate cancer risk in a nested case-control study of 1503 case subjects and 1503 control subjects among black, Latino, Japanese, Native Hawaiian, and white men from the Multiethnic Cohort study. We also examined the ability of MSP to serve as a biomarker for discriminating prostate cancer case subjects from control subjects. All statistical tests are two-sided.

Results: In all racial and ethnic groups, men with lower MSP levels were at greater risk of developing prostate cancer (odds ratio = 1.02 per one unit decrease in MSP, P < .001 in the prostate-specific antigen [PSA]-adjusted analysis). Compared with men in the highest decile of MSP, the multivariable PSA-adjusted odds ratio was 3.64 (95% confidence interval = 2.41 to 5.49) for men in the lowest decile. The positive association with lower MSP levels was observed consistently across racial and ethnic populations, by disease stage and Gleason score, for men with both high and low levels of PSA and across all genotype classes of rs10993994. However, we did not detect strong evidence of MSP levels in improving prostate cancer prediction beyond that of PSA.

Conclusions: Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer.

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Figures

Figure 1.
Figure 1.
The association of β-microseminoprotein (MSP) levels in the blood with risk of prostate cancer diagnosis is shown. The red circles are prostate-specific antigen (PSA)–adjusted odds ratios (bars show 95% confidence intervals) for each decile of MSP compared with the highest decile (black circle, reference). The blue circles are PSA-unadjusted odds ratios (bars show 95% confidence intervals) for each decile of MSP compared with the highest decile (black circle, reference). The red and blue lines show the linear association from each model starting from the highest decile of MSP. The P values are for the linear association of MSP with prostate cancer risk.
See this image and copyright information in PMC

References

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