Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:2012:386524.
doi: 10.1155/2012/386524. Epub 2012 Nov 14.

Adipocytokine levels in genetically high risk for type 2 diabetes in the Indian population: a cross-sectional study

K Subhash Chandra Bose  1 , Shachin K Gupta, Prerna Vyas
Affiliations

Adipocytokine levels in genetically high risk for type 2 diabetes in the Indian population: a cross-sectional study

K Subhash Chandra Bose et al. Exp Diabetes Res. 2012.

Abstract

Introduction: In view of the noteworthy role of adipocytokines in the onset of insulin resistance and diabetes in gene-knockout-rat-model-cell-line studies we aimed to study the influence of genetic predisposition for diabetes on adipocytokine levels and their role in building insulin-resistance-like environment well before the onset of diabetes; thus a hypothesis can be drawn on their role in developing diabetes in high risk population.

Methods: Ages between 18 and 22 years were selected and divided into three groups. Group I (n = 81): control group with no family history of diabetes. Group II (n = 157): with one of their parents with history of type 2 diabetes. Group III (n = 47): with both parents having history of type 2 diabetes. In all the groups we estimated fasting plasma glucose, insulin and adipocytokines like adiponectin, leptin, TNF-α, and IL-6.

Results: Of all adipocytokines we observed significantly lower levels of adiponectin (8.7 ± 1 μg/mL in group III and 9.5 ± 1.3 μg/mL group II) when compared to control (11.0 ± 1.2 μg/mL; P < 0.01) and it has strong correlation with family history of diabetes with Pearson's coefficient of -0.502. Linear regression analysis showed significant negative association with HOMA-IR (P < 0.01) and logistic regression analysis showed highest association with parental diabetes (P < 0.01; OR .260, 95% CI .260-.468).

Conclusion: Genetic predisposition for diabetes may influence adiponectin gene expression leading to decrease in its plasma concentration, which might play a key role in developing diabetes in near future.

PubMed Disclaimer

References

    1. IDF Diabetes Atlas. 4th edition. Brussels, Belgium: International Diabetic Federation; 2009.
    1. Ramaiya KL, Kodali NRR, Alberti KGMM. Epidemiology of diabetes in Asians of the Indian Sub-continent. International Journal of Diabetes in Developing Countries. 1991;2:15–36.
    1. Chandalia M, Abate N, Garg A, Stray-Gundersen J, Grundy SM. Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. Journal of Clinical Endocrinology and Metabolism. 1999;84(7):2329–2335. - PubMed
    1. Ramachandran A, Snehalatha C, Viswanathan V, Viswanathan M, Haffner SM. Risk of noninsulin dependent diabetes mellitus conferred by obesity and central adiposity in different ethnic groups: a comparative analysis between Asian Indians, Mexican Americans and Whites. Diabetes Research and Clinical Practice. 1997;36(2):121–125. - PubMed
    1. Sharp PS, Mohan V, Levy JC, Mather HM, Kohner EM. Insulin resistance in patients of Asian Indian and European origin with non-insulin dependent diabetes. Hormone and Metabolic Research. 1987;19(2):84–85. - PubMed

Publication types

MeSH terms