Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:2012:136087.
doi: 10.1155/2012/136087. Epub 2012 Nov 18.

Human leukocyte antigen profiles of latin american populations: differential admixture and its potential impact on hematopoietic stem cell transplantation

Affiliations

Human leukocyte antigen profiles of latin american populations: differential admixture and its potential impact on hematopoietic stem cell transplantation

Esteban Arrieta-Bolaños et al. Bone Marrow Res. 2012.

Abstract

The outcome of hematopoietic stem cell transplantation (HSCT) is shaped by both clinical and genetic factors that determine its success. Genetic factors including human leukocyte antigen (HLA) and non-HLA genetic variants are believed to influence the risk of potentially fatal complications after the transplant. Moreover, ethnicity has been proposed as a factor modifying the risk of graft-versus-host disease. The populations of Latin America are a complex array of different admixture processes with varying degrees of ancestral population proportions that came in different migration waves. This complexity makes the study of genetic risks in this region complicated unless the extent of this variation is thoroughly characterized. In this study we compared the HLA-A and HLA-B allele group profiles for 31 Latin American populations and 61 ancestral populations from Iberia, Italy, Sub-Saharan Africa, and America. Results from population genetics comparisons show a wide variation in the HLA profiles from the Latin American populations that correlate with different admixture proportions. Populations in Latin America seem to be organized in at least three groups with (1) strong Amerindian admixture, (2) strong Caucasian component, and (3) a Caucasian-African gradient. These results imply that genetic risk assessment for HSCT in Latin America has to be adapted for different population subgroups rather than as a pan-Hispanic/Latino analysis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Map showing the approximate location of the LAP included in the study.
Figure 2
Figure 2
Cluster analysis based on 47 HLA-A and HLA-B allele group frequencies among 31 LAP and 61 ancestral populations. (a) Dendrogram showing the clustering of the 92 populations. (b) Dendrogram showing the dual-clustering of HLA allele groups in the dataset. SSA: Sub-Saharan Africans; SAL: South American Lowlanders; SAA: South American Andeans; CA: Central Americans; NAA: North Americans and Alaskans; SAf: Southern Africans; EAf, Eastern Africans; CAf: Central Africans; WAf: Western Africans; Spm: Spanish minorities; Sp: Spanish; BC: Brazilians and Cubans; PIA: Portuguese, Italians, and Argentinians; NLA: Northern Latin Americans.
Figure 3
Figure 3
Principal coordinates analysis (PCO) based on the frequencies of 47 HLA-A and HLA-B allele groups in 31 LAP and 61 ancestral populations. (a) PCO map of the first 2 principal components (57.7% cumulative variance) for 61 ancestral populations from sub-Saharan Africa (SSA), America, and Europe. (b) PCO map showing the first 2 principal components (56.7% cumulative variance) for 31 LAP (blue) and 61 ancestral populations.
Figure 4
Figure 4
Frequency of ethnic-specific HLA allele groups among three subgroups of LAP and the ancestral populations. (a) Frequency of HLA-A*25 allele group as a Caucasian marker. (b) Frequency of HLA-B*42 allele group as a Sub-Saharan African (SSA) marker. (c) Frequency of HLA-B*48 as an Amerindian marker.

Similar articles

Cited by

References

    1. Ljungman P, Bregni M, Brune M, et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplantation. 2010;45(2):219–234. - PubMed
    1. Anasetti C. What are the most important donor and recipient factors affecting the outcome of related and unrelated allogeneic transplantation? Best Practice and Research: Clinical Haematology. 2008;21(4):691–697. - PMC - PubMed
    1. Dickinson AM. Risk assessment in haematopoietic stem cell transplantation: pre-transplant patient and donor factors: non-HLA genetics. Best Practice and Research: Clinical Haematology. 2007;20(2):189–207. - PubMed
    1. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110(13):4576–4583. - PubMed
    1. Shaw BE, Arguello R, Garcia-Sepulveda CA, Madrigal JA. The impact of HLA genotyping on survival following unrelated donor haematopoietic stem cell transplantation: review. British Journal of Haematology. 2010;150(3):251–258. - PubMed