doi: 10.4061/2011/428960.
Epub 2011 Dec 1.
Wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia
Affiliations
- PMID: 23213543
- PMCID: PMC3504236
- DOI: 10.4061/2011/428960
Item in Clipboard
Wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia
Leuk Res Treatment.
2011.
Abstract
Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives.
Similar articles
-
Influencing the Wnt signaling pathway in multiple myeloma.Anticancer Res. 2011 Feb;31(2):725-30. Anticancer Res. 2011. PMID: 21378363 Review.
-
CD82 supports survival of childhood acute myeloid leukemia cells via activation of Wnt/β-catenin signaling pathway.Pediatr Res. 2019 Jun;85(7):1024-1031. doi: 10.1038/s41390-019-0370-3. Epub 2019 Mar 12. Pediatr Res. 2019. PMID: 30862962
-
HOTAIRM1 knockdown enhances cytarabine-induced cytotoxicity by suppression of glycolysis through the Wnt/β-catenin/PFKP pathway in acute myeloid leukemia cells.Arch Biochem Biophys. 2020 Feb 15;680:108244. doi: 10.1016/j.abb.2019.108244. Epub 2020 Jan 2. Arch Biochem Biophys. 2020. PMID: 31904363
-
DIXDC1 promotes the growth of acute myeloid leukemia cells by upregulating the Wnt/β-catenin signaling pathway.Biomed Pharmacother. 2018 Nov;107:1548-1555. doi: 10.1016/j.biopha.2018.08.144. Epub 2018 Sep 5. Biomed Pharmacother. 2018. PMID: 30257373
-
WNT Signaling and Bone: Lessons From Skeletal Dysplasias and Disorders.Front Endocrinol (Lausanne). 2020 Apr 9;11:165. doi: 10.3389/fendo.2020.00165. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32328030 Free PMC article. Review.
Cited by
-
β-catenin induces expression of prohibitin gene in acute leukemic cells.Oncol Rep. 2017 Jun;37(6):3201-3208. doi: 10.3892/or.2017.5599. Epub 2017 Apr 25. Oncol Rep. 2017. PMID: 28440457 Free PMC article.
-
Targeting self-renewal pathways in myeloid malignancies.Cell Commun Signal. 2013 May 15;11(1):33. doi: 10.1186/1478-811X-11-33. Cell Commun Signal. 2013. PMID: 23675967 Free PMC article.
-
Pharmacological targeting of β-catenin in normal karyotype acute myeloid leukemia blasts.Haematologica. 2015 Feb;100(2):e49-52. doi: 10.3324/haematol.2014.113118. Epub 2014 Nov 7. Haematologica. 2015. PMID: 25381132 Free PMC article. No abstract available.
-
Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?Int J Mol Sci. 2016 Jun 27;17(7):1009. doi: 10.3390/ijms17071009. Int J Mol Sci. 2016. PMID: 27355944 Free PMC article. Review.
-
TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia.Blood Adv. 2023 May 23;7(10):2053-2065. doi: 10.1182/bloodadvances.2022008405. Blood Adv. 2023. PMID: 36745103 Free PMC article.
References
-
- Gilliland DG, Jordan CT, Felix CA. The molecular basis of leukemia. Hematology. 2004:80–97. - PubMed
-
- Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367(6464):645–648. - PubMed
-
- Okuhashi Y, Itoh M, Nara N, Tohda S. Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells. Anticancer Research. 2011;31(3):893–896. - PubMed
LinkOut - more resources
Full Text Sources