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. 2011:2011:428960.
doi: 10.4061/2011/428960. Epub 2011 Dec 1.

Wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia

Y Kim  1 , S Thanendrarajan, I G H Schmidt-Wolf
Affiliations

Wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia

Y Kim et al. Leuk Res Treatment. 2011.

Abstract

Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives.

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