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Review
. 2012 Dec;5(6):661-9.
doi: 10.1586/ehm.12.53.

Diagnostic methods for invasive fungal diseases in patients with hematologic malignancies

Mary Mansour Riwes  1 , John R Wingard
Affiliations
Review

Diagnostic methods for invasive fungal diseases in patients with hematologic malignancies

Mary Mansour Riwes et al. Expert Rev Hematol. 2012 Dec.

Abstract

Invasive fungal disease is associated with increased morbidity and mortality in hematologic malignancy patients and hematopoietic stem cell transplant recipients. Timely recognition and treatment of invasive fungal diseases in these patients are essential and decrease mortality. However, conventional definitive diagnostic methods are difficult and time consuming. While conventional microbiological and histopathological methods are still needed for a definitive diagnosis of invasive fungal disease, new noninvasive diagnostic methods including serologic and molecular biomarkers are now available. These new diagnostic methods facilitate an early diagnosis of invasive fungal disease and allow for utilization of a pre-emptive treatment approach, which may ultimately lead to improved treatment outcomes and reduced toxicity.

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Figures

Figure 1
Figure 1. The use of biomarker testing positivity in pre-emptive treatment approaches
HSCT: Hematopoietic stem cell transplant.
See this image and copyright information in PMC

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References

    1. Pfaller MA, Pappas PG, Wingard JR. Invasive fungal pathogens: current epidemiological trends. Clin. Infect. Dis. 2006;43(1):S3–S14.
    1. Pagano L, Caira M, Candoni A, et al. The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica. 2006;91(8):1068–1075. - PubMed
    1. Marr KA, Carter RA, Crippa F, Wald A, Corey L. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 2002;34(7):909–917. - PubMed
    1. Pagano L, Caira M, Nosari A, et al. Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study–Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne. Clin. Infect. Dis. 2007;45(9):1161–1170. - PubMed
    1. Lass-Flörl C. The changing face of epidemiology of invasive fungal disease in Europe. Mycoses. 2009;52(3):197–205. - PubMed

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