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. 2013 Sep;7(5):623-8.
doi: 10.1111/irv.12061. Epub 2012 Dec 6.

Spread of different rhinovirus B genotypes in hospitalized children in Spain

María Teresa Cuevas  1 , Mar Molinero, Francisco Pozo, Cristina Calvo, Maria Luz García-García, Noelia Reyes, Juan Ledesma, Inmaculada Casas
Affiliations

Spread of different rhinovirus B genotypes in hospitalized children in Spain

María Teresa Cuevas et al. Influenza Other Respir Viruses. 2013 Sep.

Abstract

Human Rhinovirus (HRV) classification is an evolving process. New genotypes have been described within HRV-A and HRV-C species, but only one has been accepted related to HRV-B. From 2003 to 2010, a total of 3987 nasopharyngeal aspirate samples were taken from pediatric patients admitted to the Severo Ochoa Hospital in Madrid (Spain). After viral analysis, 949 (23.8%) tested positive to HRV. A random selection of 397 (42%) positive samples showed that 39 (9.8%) were HRV-B. The sequencing of partial VP4/VP2 coding region revealed the spread of 13 of 25 defined HRV-B serotypes and three putative new genotypes. Such results remark the high diversity of HRV-B.

Keywords: Genotype; human rhinovirus; pediatric patients; respiratory infection.

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Figures

Figure 1
Figure 1
Circular phylogenetic tree of Human Rhinovirus (HRV)‐B sequences from NPA samples taken from pediatric patients. Sequences were segregated into three main clades, which are indicated with arrows. The proposed new genotypes are highlighted with the square brackets. HRV prototype strains are pointed out in boldface. Sequences similar to those analyzed in this study and retrieved from GenBank database are marked in italics. The year of sampling is indicated followed by the name of the sample. NPA, nasopharyngeal aspirate.
See this image and copyright information in PMC

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