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Comment
. 2012 Dec 5;16(6):691-2.
doi: 10.1016/j.cmet.2012.11.009.

Is hyperinsulinemia required to develop overeating-induced obesity?

Christoph Buettner  1
Affiliations
Comment

Is hyperinsulinemia required to develop overeating-induced obesity?

Christoph Buettner. Cell Metab. .

Abstract

Type 2 diabetes is characterized by insulin resistance, and the hyperinsulinemia commonly observed in patients is thought to be a compensatory response. Yet it has been difficult to disentangle cause and effect. Mehran et al. (2012) provide genetic evidence that a reduction of insulin secretion prevents high-fat feeding-induced obesity.

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