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. 2013 Sep;88(3):382-6.
doi: 10.1016/j.contraception.2012.10.034. Epub 2012 Dec 4.

Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards

Margaret C Snead  1 , Athena P Kourtis, Carolyn M Black, Christine K Mauck, Teresa M Brown, Ana Penman-Aguilar, Johan H Melendez, Maria F Gallo, Denise J Jamieson, Maurizio Macaluso
Affiliations

Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards

Margaret C Snead et al. Contraception. 2013 Sep.

Abstract

Background: Prostate-specific antigen (PSA) is a biomarker of recent semen exposure. There is currently only limited information on whether topical vaginal products affect PSA assays. We investigated this question using various dilutions of several vaginal products (lubricants and spermicides) and the Abacus ABAcard for PSA detection.

Study design: Pooled semen controls and various dilutions of nonoxynol-9 (N9), carboxymethyl cellulose (CMC), Replens, Gynol 2, K-Y jelly, Astroglide, Surgilube, combined with pooled semen dilutions, were tested for PSA using the Abacus ABAcard.

Results: N9 (2% with saline) and CMC did not appear to affect the results of testing with the ABAcard, but not all semen dilutions were tested. The other products (including Replens and Gynol, which is 2% N9 with propylene glycol, K-Y, Astroglide and Surgilube) at some of the dilutions tested either affected or gave invalid results with PSA testing using the ABAcard. Both Gynol 2 and K-Y at 1:10 dilution gave false-positive results.

Conclusions: Some vaginal products affect PSA results obtained by using the semiquantitative ABAcard. In vivo confirmation is necessary to further optimize PSA detection when topical vaginal products are present.

Keywords: ABAcard; Biomarker; Lubricants; PSA; Semen; Spermicide; Vaginal products.

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Figures

Fig. 1
Fig. 1
ABAcard.
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References

    1. Mauck CK, Doncel GF. Biomarkers of semen in the vagina: applications in clinical trials of contraception and prevention of sexually transmitted pathogens including HIV. Contraception. 2007;75:407–19. - PubMed
    1. Gallo MF, Steiner MJ, Hobbs MM, Warner L, Jamieson DJ, Macaluso M. Biological markers of semen exposure: tools for improving the assessment of sexual behavior in HIV/STI prevention research. 2012 submitted to AIDS & Behav.
    1. Graves H, Sensabaugh G, Blake E. Postcoital detection of a male-specific semen protein. Application to the investigation of rape. N Engl J Med. 1985;312:338–43. - PubMed
    1. Mauck CK, Weaver MA, Schwartz JL, Walsh T, Joanis C. Critical next steps for female condom research–report from a workshop. Contraception. 2009;79:339–44. - PubMed
    1. Rountree RW, Kilbourne-Brook M, Mauck CK, et al. SILCS diaphragm: postcoital testing of a new single-size contraceptive device. Contraception. 2008;78:237–44. - PubMed

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