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. 2013 Mar;52(3):568-75.
doi: 10.1093/rheumatology/kes324. Epub 2012 Dec 7.

Prevalence and treatment patterns of psoriatic arthritis in the UK

Alexis Ogdie  1 , Sinéad Langan, Thorvardur Love, Kevin Haynes, Daniel Shin, Nicole Seminara, Nehal N Mehta, Andrea Troxel, Hyon Choi, Joel M Gelfand
Affiliations

Prevalence and treatment patterns of psoriatic arthritis in the UK

Alexis Ogdie et al. Rheumatology (Oxford). 2013 Mar.

Abstract

Objectives: The objectives of this study were to determine the prevalence of PsA in The Health Improvement Network (THIN), a large population-based medical records database in the UK, to examine factors associated with prevalent PsA among patients with psoriasis and to describe the use of DMARDs in patients with PsA.

Methods: Two cohorts were derived from THIN to examine the prevalence of PsA in a cross-sectional study among all patients aged 18-90 years and among a subcohort of 4900 psoriasis patients aged 45-65 years. Prescription codes were used to describe therapies after the diagnosis of PsA. Associations for prevalent PsA among psoriasis patients were assessed using logistic regression analysis.

Results: Among 4.8 million patients in THIN between the ages of 18 and 90 years, 9045 patients had at least one medical code for PsA, giving an overall prevalence of 0.19% (95% CI 0.19%, 0.19%). Of those patients, 45.9% with PsA have been prescribed DMARDs. Among the 4064 confirmed psoriasis patients, the prevalence of PsA was 8.6% (95% CI 7.7%, 9.5%). PsA was more prevalent among patients with severe psoriasis [odds ratio (OR) 3.34; 95% CI 2.40, 4.65], obesity (OR 1.77; 95% CI 1.30, 2.41) and duration of psoriasis for ≥10 years (OR 7.42; 95% CI 3.86, 14.25) in the fully adjusted model.

Conclusion: The prevalence of PsA in THIN is consistent with previous population-based estimates. Limitations include a definition of PsA based on a diagnostic code rather than Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. Given the large population of PsA patients, THIN is an important resource for the study of PsA.

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Figures

F<sc>ig</sc>. 1
Fig. 1
Derivation of the cohorts. Two subcohorts were utilized in this study. The first cohort, all patients with PsA, was used to determine the prevalence of PsA in the population. The second was a subset of patients with confirmed psoriasis. This cohort was used to determine the prevalence of PsA among patients with psoriasis.
F<sc>ig</sc>. 2
Fig. 2
Age at first recorded diagnosis of PsA among all patients in the cohort by sex. The male to female ratio is presented below each age group. PsA was nearly equivalent among men and women until the oldest category, which had very few patients.
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References

    1. Siannis F, Farewell V, Cook R, Schentag C, Gladman D. Clinical and radiographic damage in psoriatic arthritis. Ann Rheum Dis. 2006;65:478–81. - PMC - PubMed
    1. Langham S, Langham J, Goertz HP, Ratcliffe M. Large-scale, prospective, observational studies in patients with psoriasis and psoriatic arthritis: a systematic and critical review. BMC Med Res Methodol. 2011;11:32. - PMC - PubMed
    1. Gladman DD, Shuckett R, Russell ML, Thorne JC, Schachter RK. Psoriatic arthritis—an analysis of 220 patients. Q J Med. 1987;238:127–41. - PubMed
    1. Gladman DD, Chandran V. Review of clinical registries for psoriatic arthritis: lessons learned? Value for the future? Curr Rheumatol Rep. 2011;13:346–52. - PubMed
    1. Eder L, Chandran V, Shen H, et al. Incidence of arthritis in a prospective cohort of psoriasis patients. Arthritis Care Res. 2011;63:619–22. - PubMed

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