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. 2012 Dec;9(12):1167-70.
doi: 10.1038/nmeth.2252.

Measuring behavior of animal models: faults and remedies

Ehud Fonio  1 , Ilan Golani, Yoav Benjamini
Affiliations

Measuring behavior of animal models: faults and remedies

Ehud Fonio et al. Nat Methods. 2012 Dec.

Abstract

Widely used behavioral assays need re-evaluation and validation against their intended use. We focus here on measures of chronic anxiety in mouse models and posit that widely used assays such as the open-field test are performed at the wrong time, for inadequate durations and using inappropriate mouse strains. We propose that behavioral assays be screened for usefulness on the basis of their replicability across laboratories.

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References

    1. Prog Neuropsychopharmacol Biol Psychiatry. 2000 May;24(4):549-60 - PubMed
    1. Behav Brain Res. 2007 Apr 16;179(1):1-18 - PubMed
    1. Psychol Bull. 1976 May;83(3):482-504 - PubMed
    1. Nat Rev Drug Discov. 2004 Aug;3(8):711-5 - PubMed
    1. Fundam Clin Pharmacol. 2007 Dec;21(6):567-74 - PubMed

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