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Comment

. 2012 Dec 7;338(6112):1303-4.

doi: 10.1126/science.1232331.

Neuroscience. Inflammation to rebuild a brain

Affiliations

PMID: 23224546
PMCID: PMC3677194
DOI: 10.1126/science.1232331

Comment

Neuroscience. Inflammation to rebuild a brain

Nephi Stella. Science. 2012.

. 2012 Dec 7;338(6112):1303-4.

doi: 10.1126/science.1232331.

Author

Affiliation

¹ Department of Pharmacology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA. nstella@u.washington.edu

PMID: 23224546
PMCID: PMC3677194
DOI: 10.1126/science.1232331

No abstract available

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Figures

Figure 1. Brain regeneration
In the zebrafish brain, injured neurons release a signal (LTC4) that stimulates resident immune cells (microglia, leukocytes, and other glia) to release a signal (LTC4) that promotes neurogenesis. The transcription factor Gata3 in both the immune cells and the neuronal progenitor cells may operate as a molecular switch that controls the repair phenotype of the inflammation.

See this image and copyright information in PMC

Comment on

Acute inflammation initiates the regenerative response in the adult zebrafish brain.
Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M. Kyritsis N, et al. Science. 2012 Dec 7;338(6112):1353-6. doi: 10.1126/science.1228773. Epub 2012 Nov 8. Science. 2012. PMID: 23138980

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References

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