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. 2012:4:319-25.
doi: 10.2147/CLEP.S35693. Epub 2012 Nov 22.

Pediatric sepsis in the developing world: challenges in defining sepsis and issues in post-discharge mortality

Matthew O Wiens  1 , Elias Kumbakumba, Niranjan Kissoon, J Mark Ansermino, Andrew Ndamira, Charles P Larson
Affiliations

Pediatric sepsis in the developing world: challenges in defining sepsis and issues in post-discharge mortality

Matthew O Wiens et al. Clin Epidemiol. 2012.

Abstract

Sepsis represents the progressive underlying inflammatory pathway secondary to any infectious illness, and ultimately is responsible for most infectious disease-related deaths. Addressing issues related to sepsis has been recognized as an important step towards reducing morbidity and mortality in developing countries, where the majority of the 7.5 million annual deaths in children under 5 years of age are considered to be secondary to sepsis. However, despite its prevalence, sepsis is largely neglected. Application of sepsis definitions created for use in resource-rich countries are neither practical nor feasible in most developing country settings, and alternative definitions designed for use in these settings need to be established. It has also been recognized that the inflammatory state created by sepsis increases the risk of post-discharge morbidity and mortality in developed countries, but exploration of this issue in developing countries is lacking. Research is urgently required to characterize better this potentially important issue.

Keywords: children; developing countries; pediatric sepsis.

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References

    1. Husak L, Marcuzzi A, Herring J, et al. National analysis of sepsis hospitalizations and factors contributing to sepsis in-hospital mortality in Canada. Healthc Q. 2010;13(Spec No:35) - PubMed
    1. Daniels R. Surviving the first hours in sepsis: getting the basics right (an intensivist’s perspective) The Journal of antimicrobial chemotherapy. 2011;66(Suppl 2):ii11–23. - PubMed
    1. Watson RS, Carcillo J. Scope and epidemiology of pediatric sepsis. Pediatr Crit Care Med. 2005;6(Suppl 3):S3–S5. - PubMed
    1. Mangia CMF, Kissoon N, Carcillo JA. Sepsis and septic shock: a global overview. J Pediatr Infect Dis. 2009;4(2):71–76. http://iospress.meta-press.com/content/k0675874488027w0/
    1. Anon. Most US adults unfamiliar with sepsis, one of nation’s leading causes of death. Available from: http://www.feinsteininstitute.org/Feinstein/Most+US+Adults+Unfamiliar+wi.... Accessed June 27, 2012.

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