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. 2012 Nov;4(5):906-912.
doi: 10.3892/etm.2012.671. Epub 2012 Aug 16.

Egg intake and bladder cancer risk: A meta-analysis

Danbo Fang  1 , Fuqing Tan, Chaojun Wang, Xuanwen Zhu, Liping Xie
Affiliations

Egg intake and bladder cancer risk: A meta-analysis

Danbo Fang et al. Exp Ther Med. 2012 Nov.

Abstract

Egg intake has been hypothesized to promote carcinogenesis due to its potential to increase circulating levels of cholesterol. Epidemiological findings regarding the association between egg consumption and risk of bladder cancer have been inconsistent. We performed a meta-analysis of the available data. Relevant studies were identified by a PubMed database search of articles dating from between January 1980 and December 2011. We identified 4 cohort and 9 case-control studies of egg intake and risk of bladder cancer. Both fixed- and random-effects models were used to calculate the summary risk estimates (REs). The combined RE of bladder cancer for the highest compared with the lowest egg intake was 0.94 (95% CI, 0.69-1.18) and weak evidence of heterogeneity was observed. The association between egg intake and risk of bladder cancer differed significantly by geographic region, with a 28% reduced risk in Japanese. Our results provided no strong evidence of a significant association of egg consumption with bladder cancer incidence but showed a protective effect in Japanese.

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Figures

Figure 1
Figure 1
Process of study selection.
Figure 2
Figure 2
Forest plots showing risk estimates from case-control and cohort studies estimating the association between egg consumption and risk for bladder cancer using (A) crude data and (B) adjusted data.
Figure 3
Figure 3
Funnel plot of egg consumption and bladder cancer risk.
See this image and copyright information in PMC

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