Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec;4(6):1027-1031.
doi: 10.3892/etm.2012.728. Epub 2012 Sep 28.

Effect of surgical intervention on the expression of leukemia inhibitory factor and L-selectin ligand in the endometrium of hydrosalpinx patients during the implantation window

Yiping Zhong  1 , Jin Li, Haitao Wu, Ying Ying, Yafeng Liu, Canquan Zhou, Yanwen Xu, Xiaoting Shen, Quan Qi
Affiliations

Effect of surgical intervention on the expression of leukemia inhibitory factor and L-selectin ligand in the endometrium of hydrosalpinx patients during the implantation window

Yiping Zhong et al. Exp Ther Med. 2012 Dec.

Abstract

The aim of this study was to investigate the effect of surgical intervention on the expression of leukemia inhibitory factor (LIF) and L-selectin ligand in the endometrium of patients with hydrosalpinx during the implantation window. A total of 60 patients with hydrosalpinx and 30 patients with tubal obstruction were recruited, and immunohistochemistry was performed to detect the expression of LIF and L-selectin ligand in the endometrium of hydrosalpinx patients before and after surgery and in the endometrium of patients with tubal obstruction. The expression of LIF and L-selectin ligand in the endometrium of hydrosalpinx patients before surgery was markedly lower than that of patients with tubal obstruction (P<0.05). Following surgery, the expression of LIF and L-selectin ligand in the endometrium of hydrosalpinx patients was comparable to that of patients with tubal obstruction (P>0.05). In addition, there was a pronounced difference in the expression of LIF and L-selectin ligand in the endometrium before and after surgery in patients with hydrosalpinx (P<0.05). Hydrosalpinx reduces the expression of LIF and L-selectin ligand in the endometrium during the implantation window. LIF and L-selectin ligand may be important factors influencing the endometrial receptivity of hydrosalpinx patients, and surgery is capable of improving the expression of LIF and L-selectin ligand in the endometrium during the implantation window.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Immunohistochemistry staining showing leukemia inhibitory factor (LIF) and L-selectin ligand expression in the endometrium in hydrosalpinx patients (A and D) before surgery, (B and E) after surgery and (C and F) in tubal obstruction patients (magnification, x400). (A–C) LIF; (D–F) L-selectin ligand.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Lessey BA. Assessment of endometrial receptivity. Fertil Steril. 2011;96:522–529. - PubMed
    1. Taylor E, Gomel V. The uterus and fertility. Fertil Steril. 2008;89:1–16. - PubMed
    1. Mijatovic V, Veersema S, Emanuel MH, et al. Essure hysteroscopic tubal occlusion device for the treatment of hydrosalpinx prior to in vitro fertilization-embryo transfer in patients with a contraindication for laparoscopy. Fertil Steril. 2010;93:1338–1342. - PubMed
    1. Seli E, Kayisli UA, Cakmak H, et al. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Hum Reprod. 2005;20:3012–3017. - PubMed
    1. Paiva P, Menkhorst E, Salamonsen L, Dimitriadis E. Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy. Cytokine Growth Factor Rev. 2009;20:319–328. - PubMed

LinkOut - more resources