Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;4(4):588-594.
doi: 10.3892/ol.2012.803. Epub 2012 Jul 16.

The role of AIB1 in breast cancer

Alan K Chang  1 , Huijian Wu
Affiliations

The role of AIB1 in breast cancer

Alan K Chang et al. Oncol Lett. 2012 Oct.

Abstract

Amplified in breast cancer 1 (AIB1) is a member of the p160 steroid receptor coactivator family that mediates the transcriptional activities of nuclear receptors including estrogen receptor (ER) and progesterone receptor (PR), as well as certain other transcription factors, including E2F1 and p53. AIB1 is widely implicated in nuclear receptor-mediated diseases, particularly malignant diseases, including breast, prostate, gastric and pancreatic cancers. AIB1 was initially implicated in hormone-dependent breast cancer, where increasing levels of AIB1 mRNA and protein were detected in some of these specimens and the overexpression of AIB1 in mice led to an increased incidence of tumors. More recent studies revealed that AIB1 also affects the growth of hormone-independent breast cancer via signaling pathways such as those of E2F1, IGF-I, EGF and PI3K/Akt/mTOR. The pleiotropic effect of AIB1 and the roles it plays in both normal development and cancer have presented a great challenge to formulating an effective therapeutic strategy for breast cancer. In this review, we highlight the significant progress made with the recent findings and present an overview of the current understanding of the influence of AIB1 on breast cancer via hormone-dependent and -independent signaling pathways.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Structural and functional domains of human AIB1. Letters within the bar indicate structural domains. Proteins that are known to interact with AIB1 are shown above and below the lines at the corresponding domains with which they interact. Only representatives of AIB1-interacting proteins are shown. For more examples of AIBI-interacting proteins, see reference . bHLH/PAS, basic helix-loop-helix/Per-ARNT-Sim; ST, serine/threonine; RID, receptor interaction domain; AD, activation domain; HAT, histone acetyltransferase domain; CARM1, coactivator-associated arginine methyltransferase-1; CBP/p300, CREB-binding protein/E1 A binding-protein; PRMT1, protein arginine methyltransferase-1.
Figure 2.
Figure 2.
Model depicting the transcriptional complex of AIB1 in steroid hormone-induced gene expression. Black dots within the nuclear receptor represent hormones. AIB1, amplified in breast cancer 1; CARM1, coactivator-associated arginine methyltransferase-1; HDAC, histone deacetylase; Ac, acetylation; M, methylation; P, phosphorylation.
Figure 3.
Figure 3.
Hormone-independent pathways through which AIB1 may participate in the development of cancer. AIB1, amplified in breast cancer 1.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Xu J, Li Q. Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol. 2003;17:1681–1692. - PubMed
    1. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. 1997;277:965–968. - PubMed
    1. Torres-Arzayus MI, Font de Mora J, Yuan J, Vazquez F, Bronson R, Rue M, Sellers WR, Brown M. High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell. 2004;6:263–274. - PubMed
    1. Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor 1 signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004;64:1875–1885. - PubMed
    1. Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005;65:7993–8002. - PubMed