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. 2012 Dec;4(6):423-4.
doi: 10.1177/1759720X12461724.

Biologic agents in rheumatoid arthritis: temporal trend of incremental benefits

Andrea Messori  1 , Dario Maratea, Valeria Fadda, Sabrina Trippoli
Affiliations

Biologic agents in rheumatoid arthritis: temporal trend of incremental benefits

Andrea Messori et al. Ther Adv Musculoskelet Dis. 2012 Dec.
No abstract available

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Conflict of interest statement

Conflict of interest statement: The authors declare no conflicts of interest in preparing this article.

Figures

Figure 1.
Figure 1.
Meta-regression analysis of temporal trends of mean difference in effectiveness between biologics and methotrexate in rheumatoid arthritis from 2000 to 2012 (12 randomized trials; data obtained from Tables 3 and 4 of Favalli et al. [2012]). The values of mean differences can be interpreted as mean improvements, if one disregards their algebraic sign. The regression equation was mean difference (%) = −64.692 + 4.590 × (YEAR − 2000); p = 0.014. Study-specific weights were calculated as inverse variance (where variance was the reciprocal of the number of patients); metaregression analysis was based on SPSS software (Version 8.1, SPSS Inc., Illinois). Symbols: each study is represented by a circle, the diameter of which is proportional to its statistical weight; grey bubbles indicate studies of early disease (N = 5) while white bubbles indicate studies of late disease (N = 7).
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References

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