Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec;4(6):423-4.
doi: 10.1177/1759720X12461724.

Biologic agents in rheumatoid arthritis: temporal trend of incremental benefits

Andrea Messori  1 , Dario Maratea, Valeria Fadda, Sabrina Trippoli
Affiliations

Biologic agents in rheumatoid arthritis: temporal trend of incremental benefits

Andrea Messori et al. Ther Adv Musculoskelet Dis. 2012 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: The authors declare no conflicts of interest in preparing this article.

Figures

Figure 1.
Figure 1.
Meta-regression analysis of temporal trends of mean difference in effectiveness between biologics and methotrexate in rheumatoid arthritis from 2000 to 2012 (12 randomized trials; data obtained from Tables 3 and 4 of Favalli et al. [2012]). The values of mean differences can be interpreted as mean improvements, if one disregards their algebraic sign. The regression equation was mean difference (%) = −64.692 + 4.590 × (YEAR − 2000); p = 0.014. Study-specific weights were calculated as inverse variance (where variance was the reciprocal of the number of patients); metaregression analysis was based on SPSS software (Version 8.1, SPSS Inc., Illinois). Symbols: each study is represented by a circle, the diameter of which is proportional to its statistical weight; grey bubbles indicate studies of early disease (N = 5) while white bubbles indicate studies of late disease (N = 7).
See this image and copyright information in PMC

References

    1. Favalli E., Pregnolato F., Biggioggero M., Meroni P. (2012) The role of biologic agents in damage progression in rheumatoid arthritis: indirect comparison of data coming from randomized clinical trials. Ther Adv Musculoskelet Dis 4: 213–223 - PMC - PubMed
    1. Messori A., Del Santo F., Fadda V., Maratea D., Trippol S. (2012a) Interpreting randomised trials evaluating newer agents or interferon in multiple sclerosis. Eur J Clin Pharmacol 68: 1225–1226 - PubMed
    1. Messori A., Fadda V., Maratea D., Trippoli S. (2012b) Meta-analysis of observational studies to evaluate immediate outcomes after endarterectomy or stenting for carotid artery stenosis. Ann Vasc Surg, in press, available at http://dx.doi.org/10.1016/j.avsg.2012.05.009 - DOI - PubMed
    1. Vasques F., Messori A., Lucenteforte E., Biancari F. (2012). Immediate and late outcome of patients aged 80 years and older undergoing isolated aortic valve replacement: a systematic review and meta-analysis of 48 studies. Am Heart J 163: 477–485 - PubMed

LinkOut - more resources